Clinical Papers

General Papers and Reviews

In Vivo Optical Coherence Tomography (OCT) in Periocular Basal Cell Carcinoma: Correlations between In Vivo OCT Images and Postoperative Histology

Lucia Pelosini, Henry Barnabas Smith, John B Schofield, Adam Meekings, Anish Dhital, Mona Khandwala

Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Br J Ophthalmol doi:10.1136/bjophthalmol-2012-303043. (2013)

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Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment

Hans Christian Ring, Mette Mogensen, Christina Banzhaf, Lotte Themstrup, Gregor B.E. Jemec

Vascular malformations commonly occur in the facial region, and can be associated with significant stigma and embarrassment. Studies have shown that even recommended light-based treatments do not always result in complete clearance. This indicates the need for more accurate pre-treatment assessment of vessel morphology to optimize treatment settings and identify possible morphological predictors of the outcome. (2013)

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Optical Coherence Tomography: Its Role in Daily Dermatological Practice

Lutz Schmitz1,*, Uwe Reinhold2, Erhard Bierhoff3, Thomas Dirschka1,4

Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. (2013)

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OCT for Monitoring and Quantification of Treatment Effects

Prof Julia Welzel, Department of Dermatology, General Hospital Augsburg, Germany, Conference communication
 
“OCT as a noninvasive imaging method allows repetitive investigation of the same skin site at several time points. Therefore, it can be used to monitor wound healing, inflammatory skin diseases like psoriasis or skin tumors during treatment.  Additionally, the severity of diseases as well as changes can be quantified by measuring the thickness of layers or the signal intensity”

Optical Coherence Tomography in Dermatology

Sattler, E., Kastle, R. & Welzel, J. (2013) “Optical coherence tomography in dermatology” J Biomed Opt, 18(6), pp. 61224 doi: 10.1117/1.JBO.18.6.061224.

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Optical Coherence Tomography in Dermatology: Technical and Clinical Aspects

Gambichler, T., Jaedicke, V. & Terras, S. (2011) “Optical coherence tomography in dermatology: technical and clinical aspects” Arch Dermatol Res, 303(7), pp. 457-473 doi: 10.1007/s00403-011-1152-x.

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Skin Cancer

Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

Chan, S. & Rohrer, T. (2012) “Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report” Case Reports in Dermatology, 4(3), pp. 269-274 doi: 10.1159/000346237.

High-resolution imaging with a multi-beam OCT device can accurately predict tumor  margins of a BCC prior to Mohs micrographic surgery. This case was particularly interesting as the margin that was mapped represented a very ill-defined area where tumor extended into almost normal appearing skin. The OCT device was able to effectively depict the tumor extension. While this report evaluated only one margin of one tumor, the potential applications of the technology are obvious. With any tumor, particularly ill-defined ones, the use of OCT could potentially reduce the number of stages required to clear the tumor leading to shorter operative times and reduction of cost. (2013).

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Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

Wang, K. X., et al. (2013) “Optical Coherence Tomography-Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study” Dermatol Surg, doi: 10.1111/dsu.12093.

The present study shows the prospective utility of using OCT to refine clinically estimated borders for MMS. OCT assessment has the potential to reduce the excised area without compromising the integrity of tumor-free borders. (2013).

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Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study

Themstrup, L., Banzhaf, C., Mogensen, M. & Jemec, G. B. (2012) “Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study” Dermatology, doi: 10.1159/000343770.

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Histological Correlates of Optical Coherence Tomography in Non-melanoma Skin Cancer

Coleman, A. J., Richardson, T. J., Orchard, G., Uddin, A., Choi, M. J. & Lacy, K. E. (2013) “Histological correlates of optical coherence tomography in non-melanoma skin cancer” Skin Res Technol, 19(1), pp. e10-19 doi: 10.1111/j.1600-0846.2012.00626.x.

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Imaging Cutaneous T-Cell Lymphoma with Optical Coherence Tomography

Christian Ring, H., Hansen, I., Stamp, M. & Jemec, G. B. (2012) “Imaging cutaneous T-cell lymphoma with optical coherence tomography” Case Rep Dermatol, 4(2), pp. 139-143 doi: 10.1159/000340010.

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Imaging Granulomatous Lesions with Optical Coherence Tomography

Banzhaf, C. & Jemec, G. B. (2012) “Imaging granulomatous lesions with optical coherence tomography” Case Rep Dermatol, 4(1), pp. 14-18 doi: 10.1159/000336000.

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Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery

Pomerantz, R. G., Zell, D., McKenzie, G. & Siegel, D. M. (2011) “Optical Coherence Tomography used as a modality to delineate basal cell carcinoma prior to Mohs micrographic surgery” Case Rep Dermatol, 3, pp. 212–218.

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Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery

Cunha, D., Richardson, T., Sheth, N., Orchard, G., Coleman, A. & Mallipeddi, R. (2011) “Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery” Br J Dermatol, 165(3), pp. 576-580 doi: 10.1111/j.1365-2133.2011.10461.x.

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Optical Coherence Tomography Used for Monitoring of PDT Treatment of Superficial Basal Cell Carcinomas

Themstrup, L., Mogensen, M. & Jemec, G. B. (2011) in “Optical Coherence Tomography Used for Monitoring of PDT Treatment of Superficial Basal Cell Carcinomas”. Presented at 22nd World Congress of Dermatology, Copenhagen.

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Optical coherence tomography – guided photodynamic therapy for skin cancer

Hamdoon, Z. (2011) in “Optical coherence tomography – guided photodynamic therapy for skin cancer”. Presented at 13th IPA World Congress Innsbruck, Austria.

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Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study

Hamdoon, Z., Jerjes, W., Upile, T. & Hopper, C. (2011b) “Optical coherence tomography-guided photodynamic therapy for skin cancer: case study” Photodiagnosis Photodyn Ther, 8(1), pp. 49-52 doi: 10.1016/j.pdpdt.2010.08.004.

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Clinical optical coherence tomography combined with multiphoton tomography for evaluation of several skin disorders

Konig, K., Speicher, M., Buckle, R., Reckfort, J., McKenzie, G., Welzel, J., Koehler, M. J., Elsner, P. & Kaatz, M. (2009) “Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases” J Biophotonics, 2(6-7), pp. 389-397 doi: 10.1002/jbio.200910013.

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General Dermatology and Cosmetics

Optical Coherence Tomography Imaging of Telangiectasias during Intense Pulsed Light Treatment: A Potential Tool for Rapid Outcome Assessment

Hans Christian Ring, Mette Mogensen, Christina Banzhaf, Lotte Themstrup, Gregor B. E. Jemec, ”Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment” Arch Dermatol Res, Online First DOI: 10.1007/s00403-013-1331-z.

 Oral Cancer

Optical Coherence Tomography in the Assessment of Suspicious Oral Lesions: An Immediate ex Vivo Study

Hamdoon, Z., Jerjes, W., Upile, T., McKenzie, G., Jay, A. & Hopper, C. (2012) “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study” Photodiagnosis Photodynamic Therapy.

This study proposes that OCT can accurately identify wide spectrum of oral tissue pathologies. Further studies can assess the role of OCT in evaluating and guiding surgical biopsies and monitoring disease. (2013).

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Optical coherence tomography in the evaluation of tongue papillae in healthy individuals

Hamdoon, Z., Jerjes, W. & Hopper, C. (2011a) “Optical coherence tomography in the evaluation of tongue papillae in healthy individuals” British Journal of Oral and Maxillofacial Surgery, 49, pp. s62-s63.

See Abstract (The abstract is not available for free)

Rheumatology & Auto Immune Diseases

Connective Tissues Diseases: Imaging Technology acts as a ‘Virtual Skin Biopsy’ in SSc

Buckland, J. (2013) “Connective Tissues Diseases: Imaging Technology acts as a ‘Virtual Skin biopsy’ in SSc” Nat Rev Rheumatol, doi: 10.1038/nrrheum.2013.37.

“Assessment of skin fibrosis is a crucial prognostic factor in SSc,” says Francesco Del Galdo, from the University of Leeds, UK, “but at present there is no objective validated biomarker to assess this.” The quest for such a biomarker is ongoing and, according to a paper from Del Galdo and colleagues in Annals of the Rheumatic Diseases, might have been achieved in the form of optical coherence tomography (OCT).

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Virtual Skin Biopsy by Optical Coherence Tomography: The First Quantitative Imaging Biomarker for Scleroderma

Giuseppina Abignano, Sibel Zehra Aydin, Concepción Castillo-Gallego, Vasiliki Liakouli1, Daniel Woods, Adam Meekings, Richard J Wakefield, Dennis G McGonagle, Paul Emery, Francesco Del Galdo, “Virtual Skin Biopsy by Optical Coherence Tomography: The First Quantitative Imaging Biomarker for Scleroderma,” Ann Rheum Dis doi:10.1136/annrheumdis-2012-202682.

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Optical Coherence Tomography Validation: A New Quantitative Imaging Biomarker For Affected Skin In Scleroderma

Abignano, G., Aydin, S., Castillo-Gallego, C., Meekings, A., Woods, D., McGonagle, D., Emery, P. & Del Galdo, F. (2012) in “Optical Coherence Tomography Validation: A New Quantitative Imaging Biomarker For Affected Skin In Scleroderma”. Presented at Conference proceedings Rheumatology, UK.

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Optical Coherence Tomography: A new tool to assess nail disease in psoriasis?

Aydin, S. Z., Ash, Z., Del Galdo, F., Marzo-Ortega, H., Wakefield, R. J., Emery, P. & McGonagle, D. (2011) “Optical coherence tomography: a new tool to assess nail disease in psoriasis?” Dermatology, 222(4), pp. 311-313 doi: 10.1159/000329434.

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A Comparison of Optical Coherence Tomography and Clinical Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

Castillo-Gallego, C., Aydin, S., Ash, Z., Abignano, G., Emery, P., Marzo-Ortega, H. & Del Galdo, F. (2011) “A Comparison of Optical Coherence Tomography and Clinical Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis” Arthritis & Rheumatism, 63.

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Optical Coherence Tomography: A New Imaging Technique That Allows Detailed Visualization of Affected Scleroderma Skin

Abignano, G., Aydin, S., Castillo-Gallego, C., Buch, M. H., Emery, P. & Del Galdo, F. (2011) “Optical Coherence Tomography: A New Imaging Technique That Allows Detailed Visualization of Affected Scleroderma Skin” Arthritis & Rheumatism, 63.

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 Nails

Optical Coherence Tomography Imaging of Onychomycosis

Nandanan, N., Fisher, J., Siegel, D. M. & Markowitz, O. (2012) in “Optical Coherence Tomography Imaging of Onychomycosis”. Presented at EADV, Florence.

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